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Recent issues cover

FoundationsAug 29, 202610 min read

HPLC Purity and LC-MS Identity Answer Two Different Questions

A certificate of analysis usually shows an HPLC purity percentage and a mass-spectrometry result. They measure different things, and neither one alone tells you the vial holds the molecule on the label.

FoundationsAug 29, 20269 min read

Endotoxin and Sterility: The Two Tests a Peptide Certificate Almost Never Includes

Purity and identity are chemistry. Endotoxin and sterility are biology, and they are measured by completely different tests that most peptide certificates of analysis never ran.

SafetyAug 28, 20268 min read

Why Peptides Degrade: The Chemistry Behind Storage and Shelf Life

Peptides break down through a small set of well-characterised chemical reactions. Here is what deamidation, oxidation, hydrolysis and aggregation actually are, why temperature and moisture drive them, and what a real stability study measures.